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  • Boosts AMPK (an enzyme that promotes energy production) in muscles by 52% and fat cells by 300%.
  • Ups ATP (energy) in your liver by 22%, which makes the liver better at ketogenesis and detoxification.
  • Amps adiponectin (a hormone from fat cells that promote fat loss and healthy blood lipids, while balancing inflammation) by up to 248%.
  • Improves insulin sensitivity by increasing glut4 (an insulin-mediated glucose transporter) by 488% in fat and muscle cells.
  • Helps lower inflammation.
  • Boosts cardiovascular health.
  • Helps reduce bad cholesterol.
  • Support fat and protein digestion.
  • Prevent digestive upset from high-fat meals.
  • Aids digestion.
  • Increases energy.
  • Reduces keto flu and fatigue during keto-adaptation.
  • Improves exercise performance, especially on low-carb or ketogenic diets.
  • Enhances fat loss (when combined with proper exercise and nutrition).
  • Improves mitochondrial health and activates anti-aging pathways.
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Get Your Digestion To The Optimal Zone


Get Your Digestion To The Optimal Zone

Get Your Digestion To The Optimal Zone

kApex® is a one of a kind supplement designed to support a ketogenic diet. Our CEO Matt Gallant has been on a ketogenic diet for 26 years and coached hundreds of people through it. He observed that many people struggle with keto flu and digestive problems, which prevent them from fully benefiting from ketosis.

kApex® is a 100% plant-based formulation that supports a smooth transition into ketosis and reduces potential side effects of keto-adaptation by:

  • Providing the digestive enzymes to help break down fats and proteins, along with dandelion root to increase bile flow
  • Increasing mitochondrial function and fat burning pathway, which optimizes ketogenesis
  • Boosting energy, cognitive function, and stamina
  • Supporting healthy trace mineral levels

Optimizing Digestion

  • Full-spectrum proteases and lipases that are active at a variety of acidity/alkalinity level
  • Dandelion root to stimulates healthy bile production and flow, and promotes liver health
  • Betaine HCl supports healthy stomach acid levels, which is important for overall digestion and gut movement
  • Astrazyme contains systemic plant-based enzymes and herbal extracts, which reduce gut inflammation and support an overall balanced immune response

Mitochondrial/Energy Production/Fat Burning Support

  • L-carnitine helps bring fatty acids into the mitochondria, which may help with fat loss
  • Ubiquinone (CoQ10) reduces oxidative stress and boosts mitochondria function, which have anti-aging effects
  • InnoslimⓇ increases the AMPK pathway, which increases energy production in ft and muscle tissues
  • Extracts of astragalus and Panax notoginseng in InnoslimⓇ and AstrazymeTM work as energy-boosting adaptogens. They boost brain function, combat fatigue, maintain metabolism, and promote performance in stressful situations, such as keto-adaptation.
  • 7-keto DHEA promotes fat burning metabolism through PPAR-alpha. It also supports healthy metabolism and promotes weight loss in combination with diet and exercise.
  • Trace minerals provide cofactors for metabolism and digestion

Benefits of Taking kApex®

  1. Optimizing Digestion

    Many new ketogenic eaters experience digestive upset from consuming a lot of fat because they start off with suboptimal digestion. kApex® contains betaine HCl, proteases, lipase, and dandelion root that promotes optimal digestion and prevents such digestive upset with high-fat meals.

  2. Support Muscle Building and Maintenance

    Ketogenic diets include much less protein than a typical bodybuilder’s meal. You may also be in a caloric deficit and can’t train as hard. These factors may make it harder to preserve and build muscles. A key to preserving muscles and exercise performance throughout keto-adaptation is to ensure that the proteins you eat count. The proteases in kApex® ensure that all the proteins you eat are fully broken down, so that the amino acids are absorbed.

    The dandelion root stimulates bile production, whereas lipases that are active at varying acidity ensure that the fats are fully broken down.

    Ketogenic diets include much less protein than a typical bodybuilder’s meal. The key to preserving muscles throughout keto-adaptation is to ensure that the proteins you eat count. The proteases in kApex® ensure that all the proteins you eat are fully broken down, so that the amino acids are absorbed.

  3. Improving Energy, Cognitive Function, and Well-Being

    Many new keto eaters experience keto flu, which include temporary fatigue, brain fog, and decreases in performance. Keto-adaptation calls upon your stress response system to provide energy before your body can optimally burn ketones for energy. kApex® addresses these sticking points with energizing ingredients in InnoSlim, 7-keto DHEA, and trace minerals. These ingredients energize you by speeding up your metabolism and working as adaptogens to support your stress response system. Even when you are keto-adapted but have yet to reach full metabolic-flexibility for high-intensity exercise performance to return, the energizing ingredients in kApex® can help bridge the gap.

  4. Increasing Fat Burning For Energy

    Your mitochondria is the fat burning furnace inside your cells. Poor mitochondria function can cause fatigue, brain fog, weight gain, and worse transition to a ketogenic diet.

    kApex® supports your mitochondria function with L-carnitine, CoQ10, and Innoslim.

  5. Boosting Insulin Sensitivity and Promoting Healthy Blood Lipids

    The synergistic components in Innoslim increase the glucose transporter 4 (Glut4) to the surface of your fat and muscle cells, increasing the amount of glucose these cells absorb. Therefore, kApex® can ensure that glucose and other nutrients reach your muscle cells and help them grow, even in the low insulin environment of low-carb or ketogenic diets.

  6. Promoting a Balanced Immune Response

    The synergistic components in kApex®, including Innoslim and Astrazyme, promote a balanced immune response.

  7. Anti-Aging

    Ketogenic diets typically have an anti-aging effect by boosting the mitochondria, while reducing inflammation and oxidative stress. kApex® augments these benefits by optimizing the mitochondria, promoting balanced inflammation and stress responses, and reducing oxidative stress.

  8. Cholesterol and Triglyceride

    Also, by stimulating the AMPK enzyme, Innoslim inhibits cholesterol and triglyceride synthesis in the liver. Also, since cholesterol increases with inflammation, reducing inflammation tends to reduce cholesterol. The herbal ingredients and systemic enzymes in Astrazyme and Innoslim promote a balanced inflammatory response. Therefore, Innoslim may promote healthy cholesterol and triglyceride levels in combination with diet and exercise.

How kApex® Work?

kApex® supports digestive function, especially for low-carb ketogenic meals, with full-spectrum enzymes that digest fat and proteins. It also promotes healthy fat metabolism and supports a healthy stress response, which makes it easier to enter and stay in ketosis.

kApex® can boost your workout and keep your brain lit for hours without crashes, jitters, or burnouts.

Suggested Use

Take 2-4 capsules with each meal and 4-6 capsules on an empty stomach upon waking.

Do not take kApex® after 5pm since you may experience excess energy at night and loss of sleep.

Keep refrigerated once opened.

Consult your medical practitioner prior to starting any new supplement.

When To Take kApex®?

Because kApex® contains energizing ingredients, it is best to consume kApex® early in the day.

For optimal performance and mitochondrial support, start with 3 - 8 capsules (depending on bodyweight) before breakfast first thing in the morning.

For digestion, take 1 - 3 capsules with breakfast and lunch. For dinner, use MassZymes and HCl Breakthrough instead.

If you have trouble sleeping when you take it with lunch, then only take it with breakfast.

Digestive Problems on Low Carb Diet

Some people experience constipation on low-carb diets because they contain less dietary fiber. The solution is to increase your fiber intake and drink more water.

Others experience digestive upset, bloating, diarrhea associated with high-fat ketogenic meals. The solution is to use digestive support, such as digestive enzymes, HCl, and probiotics, that can boost fat digestion. Also, sugar alcohols and MCT oils, which are common ingredients in keto processed foods, can cause diarrhea and gas, and should be avoided if you suffer from digestive problems.

kApex Questions:
Why does kApex® need to be refrigerated once opened?

Once kApex® is opened, the oxygen in the air will start oxidizing 7-keto DHEA. The cold temperature slows down the oxidation process.

What is the shelf life for kApex®?

The shelf life for kApex® is 2 years from the manufactured date, which can be found on the bottle.

Any medical conditions that warrant discontinuing the use of kApex®?

Do not use kApex® if an ulcer or gastritis are present or if you are allergic to any of the ingredients. If any adverse side effects occur, discontinue immediately.

Consult your medical practitioner prior to starting any new supplement, diet, or training program, or if you are undergoing treatment for a medical condition.

kApex® contains ingredients that are banned by the World Anti-Doping Association (WADA). Therefore, it is not apt for professional athletes.

Do you have to follow a keto diet to take kApex®?

You do not have to follow a keto diet to consume this product. kApex® is designed to improve digestion, consumption of nutrients, boost energy levels, and much more. Everyone, regardless of diet type, can enjoy these benefits.

What is the recommended dosage for kApex®?

The recommended dose for kApex® is 1 capsule per every 44 lbs (depending on weight, this could range from 3-8 capsules) on an empty stomach upon waking in the morning.

To improve digestion of the food you consume, take 1-3 capsules with meals. However, be cautious at dinner since you may experience excess energy at night and loss of sleep.

Is it okay for pregnant or breastfeeding mothers to take kApex®?

Pregnant or breastfeeding mothers should consult a medical practitioner prior to starting any new supplement, diet, or training program.

When is the best time to take kApex®?

The best time is to take 4 - 8 capsules first thing in the morning on an empty stomach, and 2 - 4 capsules with lunch. Taking it too late in the afternoon or evening can keep you up at night. To support digestion at dinner, use MassZymes instead.

How many capsules in a kApex® bottle?

The kApex® bottle contains 120 capsules.

Frequently Asked Questions:
What supplements help with fat digestion?

The following supplements can help with fat digestion:

  • Bitters such as dandelion root
  • Bile salt supplement, although these only come from animal sources
  • Plant-based emulsifier, such as lecithin
  • Lipases, or fat digesting enzymes
How can I increase my AMPK naturally?

AMPK (AMP-activated protein kinase) is an energy sensor inside your cells. When energy (ATP) levels are low, AMPK kicks in to increase fat burning, stimulate your mitochondria, promotes cellular self-cleanup, and increases insulin sensitivity.

Ways to increase AMPK naturally include:

  • Exercise
  • Fasting and caloric restriction
  • Ketogenic diets
  • Managinginflammation<
  • Cold exposure
  • Taking specific extracts of Notoginseng and astragalus, such as in Innoslim
Does AMPK help lose weight?

It depends on where. Activating AMPK can stimulate your mitochondria, increasing fat burning and helping with weight loss. However, activating AMPK in the hypothalamus in your brain can increase appetite. The pathways activated by Innoslim mainly work inside fat and muscle cells.

What are the side effects of AMPK?

AMPK is a natural substance found in all cells of your body. It is possible that activating it too much can lead to side effects. For example, AMPK participates in some pathways that prevent neurodegenerative diseases and cancers, but also play some roles in pathways that promote these diseases. Drugs that stimulate AMPK, such as metformin and salicylates have their own side effects. Whereas, Innoslim does not have the same side effects as these drugs.

Why does the liver need ATP?

The liver is a metabolically active organ. It takes a lot of energy to metabolize all the toxins in the body into forms that can be safely eliminated. The liver is also responsible for producing bile, which helps digest fat, and burning fat into ketones.

What are signs that your liver is not functioning properly?
  • Poor digestion and constipation
  • Inability to lose weight
  • Hormone imbalances
  • Fatigue
  • Skin breakouts
  • High cholesterol
  • Inability to tolerate alcohol or chemical exposure
  • Headache
How Can I Boost My Keto Diet?
  • Make sure you consume enough salt, minerals, and fat
  • Ensure that your liver is working well before attempting keto
  • Eating a balanced fatty acid intake (mention Keto Balance here?)
  • Consuming enough vegetables and antioxidants
  • Managing stress and consuming enough magnesium
  • Not being in a caloric deficit that is too aggressive for your body
  • Using refeed meals or days
  • Ensuring that your digestive function is optimal.
  • Managing inflammation
  • Supporting mitochondrial health, such as with carnitine and CoQ10
  • Supporting your gut barrier and gut bacteria with P3OM and Leaky Gut Guardian

kApex® contains dandelion root and enzymes specifically optimized for ketogenic diets. The systemic enzymes in kApex® can help balance inflammation. It also contains mitochondria support ingredients, such as carnitine, CoQ10, and Innoslim.

Is a Paleo Diet good for gut health?

The term “Paleo Diet” is a dietary philosophy based on the archaeological principles of the foods that were available to hunter-gatherers. It advocates for the omission of grains, legumes, sugar, processed foods, and dairy, which often by default causes the diet to become low-carb. However, the Paleo diet is a broad descriptor that can include anywhere between a carnivore (no plant) diet to a mostly plant diet with sprinkles of animal products.

Some aspects of Paleo could be good for gut health. These include the avoidance of grain-fed animal products that are high in pesticides and antibiotics. Paleo also advocates high-antioxidant and high-fiber vegetables and fermented foods, which are good for the gut bacteria..

For some people who are sensitive to lectins, gluten, other plant anti-nutrients, and dairy, eliminating grains and legumes often heal their gut. However, grains and legumes are also great sources of resistant starch for people who are not sensitive to these foods. There are some concerns that people who are on low or very low-carb Paleo versions could be starving their gut bacteria. Whether the Paleo diet is good or bad for the gut depends on whether the diet is compatible with their physiology.

What are the side effects of a Paleo Diet?

Many people transition into a Paleo diet by just removing the grain-containing foods, which leaves them only between 50 - 100 grams of carbs, including vegetables. In these cases, they may be on a low carbohydrate diet, which can cause similar side effects as keto adaptation, including:

  • Carbohydrate cravings
  • Fatigue, brain fog, and irritability
  • Digestive symptoms
  • Bad breath

In most cases, the high protein consumption in the Paleo diet will prevent full-on ketosis, although it is normal to experience carb withdrawal symptoms. However, once your body learns to harness more energy from fat (keto-adapted), these symptoms will go away. kApex® can support healthy energy production, especially from fats, which helps you seamlessly adapt to ketosis. It also contains a well-researched blend of betaine HCl, digestive enzymes, and dandelion root to support your digestion.

Is Paleo healthier than Keto?

Both Paleo and Keto are significant upgrades compared to the Standard American Diet. These two terms are different, although not mutually exclusive.

The Paleo diet recommends low-toxin and nutrient-dense foods, which are ideally organic and local. The food should also be grown according to its natural conditions, such as grass-fed cattle, wild-caught fish, and free-range eggs. The diet recommends plenty of fresh vegetables, fruits, nuts and seeds, high-quality meats, eggs, fish and seafood, and spices. Natural monounsaturated and nutrient-dense saturated fats, such as olive oil, avocadoes, tallow, lard, and coconut are recommended. Whereas, grains, legumes, vegetable oils, dairy, sugar, artificial sweeteners, and processed foods are recommended against.

The diet doesn’t specify a macronutrient composition, but rather leave it to the individual to decide what works best for them. Most Paleo eaters follow a low to moderate carbohydrate version, which is much less than what most Americans consume in a Standard American Diet. However, some athletes add a lot more fruits and tubers to support their training, while some Paleo eaters deliberately increase the fats to make it ketogenic.

The ketogenic diet refers to any diet that is very high in fat and very low in carbohydrates, with a goal of entering ketosis. The food does not have to be natural, organic, or local. Some keto eaters consume a lot of dairy and even vegetable oils, whereas others stick to natural and nutrient-dense foods.

The ketogenic diet, or the presence of ketone bodies in the blood, have some medicinal potential that the paleo diet doesn’t. For example, it can help manage treatment-resistant epilepsy. Also, many clinical studies are ongoing to evaluate other potential medicinal properties of ketogenic diet. If you are working with your doctor to manage a health condition with a ketogenic diet, then the ketogenic diet might be healthier for you. In such cases, you need to speak to your doctor before introducing any supplements.

We advocate for nutrient-dense, whole, and natural foods, when possible. Also, we recommend choosing the diet that works best for you based on how you feel and your health markers after the initial adaptation period. Neither diet is suitable for everyone, but kApex® can help make the adaptation period easier.

What is the role of adiponectin?

Adiponectin is a small protein hormone produced by fat cells. It helps reduce inflammation, increase fat burning, promotes insulin sensitivity, and promotes heart and blood vessel health.

How do I increase my adiponectin levels?
  • Consuming enough omega-3
  • Consuming less carbohydrates.
  • Consuming more monounsaturated fats, such as olive oil, avocados, and macadamia
  • Consuming fiber may increase adiponectin by 60 - 115%.
  • Exercise
  • Cold thermogenesis
  • Using kApex®
What is the role of glut4?

Glut4 is a glucose transporter in fat and muscle cells. It brings glucose into the cells once triggered by insulin. When someone is insulin resistant, it’s because they have a problem with Glut4, such as lacking glut4 on the cell surface or that glut4 doesn’t function correctly.

How do you increase glut4?
  • Exercise
  • Consuming less carbohydrates
  • Caloric restriction and fasting
  • Vitamin D
  • Ginseng extracts in kApex®
How can I lower my LDL cholesterol naturally?
  • Lowering saturated fat intake and replace it with monounsaturated fats instead
  • Consuming more fiber
  • Optimizing your gut health and microbiome, as high bacterial toxin in the blood due to leaky gut can increase LDL cholesterol. Leaky Gut Guardian promotes a healthy gut barrier and binds up some bacterial toxins.
  • Restoring insulin sensitivity reduces the more dangerous (small and dense) LDL
Can you increase the number of mitochondria in your body?
  • Exercise
  • Ketogenic diet
  • Caloric restriction/fasting
  • Cold exposure
  • Dietary antioxidants in fruits and vegetables
kApex | Supports Ketogenesis
  • Made in USA
  • FDA Approved
  • NSF Certified
  • GMP Certified
  • Manufacturing COA

Product Information

Product Dimensions:

  • Cap diameter: 1.5 inches
  • Bottom diameter: 2 inches
  • Height: 4.5 inches
  • Weight: 3.6 ounces


Do not use if ulcer or gastritis are present.

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kApex Reviews

Scientific Studies
  1. Mahboubi M, Mahboubi M. Hepatoprotection by dandelion (Taraxacum officinale) and mechanisms. Asian Pac J Trop Biomed. 2020;10(1):1-10. doi:10.4103/2221-1691.273081
  2. Guilliams TG, Drake LE. Meal-Time Supplementation with Betaine HCl for Functional Hypochlorhydria: What is the Evidence?. Integr Med (Encinitas). 2020;19(1):32-36.
  3. Talenezhad N, Mohammadi M, Ramezani-Jolfaie N, Mozaffari-Khosravi H, Salehi-Abargouei A. Effects of l-carnitine supplementation on weight loss and body composition: A systematic review and meta-analysis of 37 randomized controlled clinical trials with dose-response analysis. Clin Nutr ESPEN. 2020;37:9-23. doi:10.1016/j.clnesp.2020.03.008
  4. Tian G, Sawashita J, Kubo H, et al. Ubiquinol-10 supplementation activates mitochondria functions to decelerate senescence in senescence-accelerated mice. Antioxid Redox Signal. 2014;20(16):2606-2620. doi:10.1089/ars.2013.5406
  5. Webb SJ, Geoghegan TE, Prough RA, Michael Miller KK. The biological actions of dehydroepiandrosterone involves multiple receptors. Drug Metab Rev. 2006;38(1-2):89-116. doi:10.1080/03602530600569877
  6. Kaiman DS, Colker CM, Swain MA, Torina GC, Shi Q. A randomized, double-blind, placebo-controlled study of 3-acetyl-7-oxo-dehydroepiandrosterone in healthy overweight adults. Curr Ther Res Clin Exp. 2000;61(7):435-442.
  7. Roberts MN, Wallace MA, Tomilov AA, et al. A Ketogenic Diet Extends Longevity and Healthspan in Adult Mice [published correction appears in Cell Metab. 2018 May 1;27(5):1156]. Cell Metab. 2017;26(3):539-546.e5. doi:10.1016/j.cmet.2017.08.005
  8. Foretz M, Viollet B. Activation of AMPK for a Break in Hepatic Lipid Accumulation and Circulating Cholesterol. EBioMedicine. 2018;31:15-16. doi:10.1016/j.ebiom.2018.05.009
  9. Tsoupras A, Lordan R, Zabetakis I. Inflammation, not Cholesterol, Is a Cause of Chronic Disease. Nutrients. 2018;10(5):604. Published 2018 May 12. doi:10.3390/nu10050604
  10. Marzin T, Lorkowski G, Reule C, et al. Effects of a systemic enzyme therapy in healthy active adults after exhaustive eccentric exercise: a randomised, two-stage, double-blinded, placebo-controlled trial. BMJ Open Sport Exerc Med. 2017;2(1):e000191. Published 2017 Mar 12. doi:10.1136/bmjsem-2016-000191
  11. Herzig S, Shaw RJ. AMPK: guardian of metabolism and mitochondrial homeostasis. Nat Rev Mol Cell Biol. 2018;19(2):121-135. doi:10.1038/nrm.2017.95
  12. Huynh MK, Kinyua AW, Yang DJ, Kim KW. Hypothalamic AMPK as a Regulator of Energy Homeostasis. Neural Plast. 2016;2016:2754078. doi:10.1155/2016/2754078
  13. Bujak AL, Crane JD, Lally JS, et al. AMPK activation of muscle autophagy prevents fasting-induced hypoglycemia and myopathy during aging. Cell Metab. 2015;21(6):883-890. doi:10.1016/j.cmet.2015.05.016
  14. Paoli A, Bosco G, Camporesi EM, Mangar D. Ketosis, ketogenic diet and food intake control: a complex relationship. Front Psychol. 2015;6:27.
  15. Burkewitz K, Zhang Y, Mair WB. AMPK at the nexus of energetics and aging. Cell Metab. 2014;20(1):10-25. doi:10.1016/j.cmet.2014.03.002
  16. Wu L, Zhang L, Li B, et al. AMP-activated protein kinase (AMPK) regulates energy metabolism through modulating thermogenesis in adipose tissue. Front Physiol. 2018;9. doi:10.3389/fphys.2018.00122
  17. Garcia D, Hellberg K, Chaix A, et al. Genetic liver-specific AMPK activation protects against diet-induced obesity and NAFLD. Cell Rep. 2019;26(1):192-208.e6
  18. Scerif M, Kola B, Korbonits M. Ghrelin regulation of AMPK in the hypothalamus and peripheral tissues. In: Smith RG, Thorner MO, eds. Ghrelin in Health and Disease. Contemporary Endocrinology, vol 10. Humana Press, Totowa, NJ. 2012:91-110
  19. Kubota N, Yano W, Kubota T, et al. Adiponectin stimulates AMP-activated protein kinase in the hypothalamus and increases food intake. Cell Metab. 2007;6(1):55-68. doi:10.1016/j.cmet.2007.06.003
  20. Kossoff EH, Dorward JL. Ketogenic Diets. In: The Treatment of Epilepsy. Wiley-Blackwell. 2009:301-310.
  21. Achari AE, Jain SK. Adiponectin, a Therapeutic Target for Obesity, Diabetes, and Endothelial Dysfunction. Int J Mol Sci. 2017;18(6):1321. Published 2017 Jun 21. doi:10.3390/ijms18061321
  22. Gray B, Steyn F, Davies PS, Vitetta L. Omega-3 fatty acids: a review of the effects on adiponectin and leptin and potential implications for obesity management. Eur J Clin Nutr. 2013;67(12):1234-1242. doi:10.1038/ejcn.2013.197
  23. Song X, Kestin M, Schwarz Y, et al. A low-fat high-carbohydrate diet reduces plasma total adiponectin concentrations compared to a moderate-fat diet with no impact on biomarkers of systemic inflammation in a randomized controlled feeding study. Eur J Nutr. 2016;55(1):237-246. doi:10.1007/s00394-015-0841-1
  24. Paniagua JA, Gallego de la Sacristana A, Romero I, et al. Monounsaturated fat-rich diet prevents central body fat distribution and decreases postprandial adiponectin expression induced by a carbohydrate-rich diet in insulin-resistant subjects. Diabetes Care. 2007;30(7):1717-1723. doi:10.2337/dc06-2220
  25. Silva FM, de Almeida JC, Feoli AM. Effect of diet on adiponectin levels in blood. Nutr Rev. 2011;69(10):599-612. doi:10.1111/j.1753-4887.2011.00414.x
  26. Becic T, Studenik C, Hoffmann G. Exercise Increases Adiponectin and Reduces Leptin Levels in Prediabetic and Diabetic Individuals: Systematic Review and Meta-Analysis of Randomized Controlled Trials. Med Sci (Basel). 2018;6(4):97. Published 2018 Oct 30. doi:10.3390/medsci6040097
  27. Imbeault P, Dépault I, Haman F. Cold exposure increases adiponectin levels in men. Metabolism. 2009;58(4):552-559. doi:10.1016/j.metabol.2008.11.017
  28. Richter EA, Hargreaves M. Exercise, GLUT4, and skeletal muscle glucose uptake. Physiol Rev. 2013;93(3):993-1017.
  29. Kubota M, Koshinaka K, Kawata Y, Koike T, Oshida Y. Effects of continuous low-carbohydrate diet after long-term exercise on GLUT-4 protein content in rat skeletal muscle. Horm Metab Res. 2008;40(1):24-28. doi:10.1055/s-2007-1004530
  30. Gazdag AC, Sullivan S, Kemnitz JW, Cartee GD. Effect of long-term caloric restriction on GLUT4, phosphatidylinositol-3 kinase p85 subunit, and insulin receptor substrate-1 protein levels in rhesus monkey skeletal muscle. J Gerontol A Biol Sci Med Sci. 2000;55(1):B44-6; discussion B47-8.
  31. Manna P, Jain SK. Vitamin D up-regulates glucose transporter 4 (GLUT4) translocation and glucose utilization mediated by cystathionine-γ-lyase (CSE) activation and H2S formation in 3T3L1 adipocytes [published correction appears in J Biol Chem. 2013 Aug 23;288(34):24871]. J Biol Chem. 2012;287(50):42324-42332. doi:10.1074/jbc.M112.407833
  32. Guo X, Sun W, Luo G, et al. Panax notoginseng saponins alleviate skeletal muscle insulin resistance by regulating the IRS1-PI3K-AKT signaling pathway and GLUT4 expression. FEBS Open Bio. 2019;9(5):1008-1019. doi:10.1002/2211-5463.12635
  33. Topchiy E, Cirstea M, Kong HJ, et al. Lipopolysaccharide Is Cleared from the Circulation by Hepatocytes via the Low Density Lipoprotein Receptor [published correction appears in PLoS One. 2016;11(7):e0160326]. PLoS One. 2016;11(5):e0155030. Published 2016 May 12. doi:10.1371/journal.pone.0155030
  34. Mykkänen L, Haffner SM, Rainwater DL, et al. Relationship of LDL size to insulin sensitivity in normoglycemic men. Arterioscler Thromb Vasc Biol. 1997;17(7):1447-1453.
  35. Menshikova EV, Ritov VB, Fairfull L, et al. Effects of exercise on mitochondrial content and function in aging human skeletal muscle. J Gerontol A Biol Sci Med Sci. 2006;61(6):534-540. doi:10.1093/gerona/61.6.534
  36. Miller VJ, Villamena FA, Volek JS. Nutritional Ketosis and Mitohormesis: Potential Implications for Mitochondrial Function and Human Health. J Nutr Metab. 2018;2018:5157645. Published 2018 Feb 11. doi:10.1155/2018/5157645
  37. Chung N, Park J, Lim K. The effects of exercise and cold exposure on mitochondrial biogenesis in skeletal muscle and white adipose tissue. J Exerc Nutrition Biochem. 2017;21(2):39-47. doi:10.20463/jenb.2017.0020
  38. Holmström KM, Kostov RV, Dinkova-Kostova AT The multifaceted role of Nrf2 in mitochondrial function. Curr Opin Toxicol. 2016;1:80-91. doi:10.1016/j.cotox.2016.10.002

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