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Why Getting ALL 7 Forms of Magnesium Transforms Your Stress & Performance
One of the biggest misconceptions about magnesium is that you just “need more” of it and you’ll be healthy and optimized.
But the TRUTH is, there are many different types of magnesium — and each plays a critical role in different functions in your body.
Most “healthy” people only get 1-2 forms at best (much of the population is deficient in all forms) — but when you get all 7 major forms of magnesium, that’s when the magic happens.
Magnesium Chelate
This form of magnesium is especially important for muscle building, recovery, and health.
Magnesium Citrate
Helps with the effects of obesity. In fact, one study found that this form helped arterial stiffness in healthy overweight individuals.
Magnesium Bisglycinate
Often used to treat symptoms of excess stomach acid, such as stomach upset, heartburn, and acid indigestion.
Magnesium Malate
Some believe this to be the most bioavailable form of magnesium. It’s found naturally in fruits, giving them a “tart taste.”
Magnesium Malate can help with migraines, chronic pain, and depression.
Magnesium Sucrosomial
This form of magnesium helps you to effectively produce energy. It also supports the immune system and is critical for bone health and skeletal development.
Magnesium Taurate
This is the form of magnesium best for your heart.
One study noted: “The complex magnesium taurate may thus have considerable potential as a vascular-protective nutritional supplement.”
Magnesium Orotate
While also helpful for the heart, magnesium orotate is believed to be the best form for metabolic improvements.
This makes it a favorite for athletes seeking enhanced recovery, energy and performance.
Getting ALL of these forms of magnesium, in the optimum dose, upgrades virtually every function in your body.
| Ingredients | BiOptimizers Magnesium Breakthrough | Strength Sensei Quadra Mag | Livewell Magwell | Zeal Naturals Magnesium | Natural Rhythm Triple Calm Magnesium | BioEmblem Triple Magnesium Complex | Terranics Magnesium Complex | Life Extension Magnesium Caps |
|---|---|---|---|---|---|---|---|---|
| Glycinate | ||||||||
| Taurate | ||||||||
| Orotate | ||||||||
| Sucrosomial | ||||||||
| Citrate | ||||||||
| Chelate | ||||||||
| Malate |
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Get Your Magnesium Level To The Optimal Zone
Why Magnesium Breakthrough:
Magnesium is one of the most important minerals for all aspects of health. It participates in over 600 different biochemical reactions in your body. Yet, over 80% of the population don’t get the minimum amounts of the types of magnesium they need from diet alone because US soil is lacks it. Magnesium deficiency can increase all disease risks and keep you from performing optimally.
Even people who supplement tend to take types that are poorly absorbed, or they only take two types of magnesium at most. Each type benefits different tissues and organ systems. If you’re only taking one or two forms, you’re most likely still deficient.
BiOptimizers Magnesium Breakthrough is the only supplement on the market that to offer the full spectrum of all seven types of magnesium specially formulated to reach every tissue in your body to provide maximum health benefits and reverses low levels which could be causing health issues.
Magnesium and Anxiety
Magnesium is extremely important for mental and neurological health. Studies have shown that magnesium deficiency causes animals to be stressed and anxious. In humans, a low-magnesium diet is associated with anxiety and depression. You need magnesium to deal with stress. Stress causes you to excrete more magnesium through urine Therefore, being deficient can create anxiety.
Magnesium supplementation has been shown to promote a healthy stress response and reduce neurotransmitters that cause anxiety. It also promotes relaxation by increasing GABA, the calming neurotransmitter.
In a randomized controlled trial of mildly anxious subjects, magnesium + vitamin B6 significantly reduced stress scores compared to the placebo.
Magnesium supplements have also been shown to help improve mental health in women with premenstrual syndrome and postpartum anxiety.
To boost mood, reduce anxiety, and promote a healthy stress response, it is best to use a combination of forms of magnesium combined with vitamin B6. Studies have confirmed that magnesium with organic acid salt (e.g. citrate and malate) or amino acids (e.g. taurate, glycinate, and sucrosomial) are significantly better absorbed than inorganic salts (oxide, chloride, and sulfate). Also, these different forms are absorbed into different tissues, with taurate, malate, and citrate being the most beneficial for the nervous system
BiOptimizers Magnesium Breakthrough contains the full spectrum of all seven forms of the most bioavailable magnesium along with vitamin B6 to support mental health and promote a healthy stress response.
Magnesium Breakthrough Benefits
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Promotes Heart Health
Magnesium is extremely important for heart health and blood vessel health. Magnesium deficiency seems to worsen the inflammation, blood vessel constriction, blood clotting, and stress responses that trigger heart conditions. Correcting deficiency appears to improve heart health and reduces risk of deaths, although it is unclear whether supplementation alone is sufficient to treat these conditions.
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Improves the Ability to Deal With Stress and Helps to Relax
A magnesium supplement significantly reduced stress in people who are deficient in magnesium. Also, combined with vitamin B6 was 40% more helpful than alone for severe stress. Findings support the need for magnesium supplementation for people living in conditions of chronic stress.
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Helps With Mood, Cognitive Function, and Mental Health
A magnesium supplement significantly improved mood after 2 weeks. Another trial found that magnesium supplements improved mood in seniors with type 2 diabetes.
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Promotes Healthy Blood Sugar Hormone Function And Promotes Healthy Metabolism
Magnesium is important for hormones that regulate bloog sugar to function well. Therefore, many people with blood sugar issues, metabolic syndrome, and diabetes are deficient in magnesium. Even when diabetes is well-controlled, a supplement would still be necessary to achieve healthy levels. In a clinical trial involving 65 diabetes patients, magnesium supplementation promotes healthy function and metabolism.
A large-scale systematic and dose-response analysis found that magnesium supplementation correlated with reduced body weight and waist circumference among specific groups of people. Those with resistance, hypertension, obesity, magnesium deficiency, and women seem to weigh less and had smaller waist circumference if they took magnesium supplements.
In pregnant women with gestational diabetes, magnesium supplementation improved blood glucose control and pregnancy outcomes.
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Supports exercise performance and recovery
Magnesium supplementation improves speed and strength, possibly by making glucose metabolism more efficient. It also supports the necessary stress response to exercise, reduces muscle damage, and improves exercise recovery (400 mg/day, taken at breakfast).
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Improves Sleep Quality
In a small clinical trial involving 46 elderly subjects with insomnia, 500 mg of daily magnesium supplement reduced insomnia scores, sleep latency, and cortisol. Subjects also had more serum melatonin, slept deeper, and were less likely to wake up in the middle of the night.
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Builds Stronger Bones
Magnesium is a key building blocks of your bones. Magnesium deficiency can contribute to osteoporosis by:
- preventing healthy bone formation, creating brittle bones
- causing low-grade inflammation
- increasing cortisol, which can contribute to bone loss
- reducing parathyroid hormone
In a clinical trial involving 73,684 postmenopausal women, low magnesium intake was associated with lower bone density in the hip and whole body. Magnesium intake slightly higher than the Recommended Dietary Allowance was associated with lower arm and wrist factures from falling.
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Promotes Healthy Blood Pressure
A meta-analysis of 34 randomized control trials found that magnesium reduced blood pressure. However, the effect size is clinically small (<2 mmHg). Therefore, it may be good for supporting overall health and healthy blood pressure, but you may also need other interventions to achieve healthy blood pressure levels.
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Promotes Balanced and Healthy Immune System
Magnesium deficiency increases inflammation. In a meta-analysis involving 32,198 people, those with more magnesium had less serum C-reactive protein (a marker of inflammation).
Overall, magnesium deficiencies tend to exacerbate or increase the risk of conditions that involve chronic inflammation.
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Supports Vitamin D Activation and Metabolism
Both Vitamin D and magnesium have important roles in bone health, immune function, and metabolism. Magnesium is a cofactor in vitamin D conversion and activation. Some people cannot increase their blood 25-hydroxy vitamin D levels despite supplementing with vitamin D3 because they are deficient. In other words, magnesium deficiency can make vitamin D ineffective.
Also, in people deficient, high doses of vitamin D3 could worsen magnesium deficiency and increase the potential for side effects of vitamin D3, such as having calcium deposits in the arteries.
How To Take Magnesium
When you take magnesium in the morning, it supports brain function and stress response throughout the day. In the evening, high doses of magnesium promote relaxation and may help with sleep. Therefore, it is best to divide your magnesium supplement doses throughout the day. If that is not possible, take whenever you can.
It is better to take mineral supplements, such as magnesium, on an empty stomach because you will absorb it more efficiently. However, some people experience upset stomach, so they take it with food.
Studies of inorganic magnesium salts (oxide, chloride, and sulfate) found that stomach acid is necessary for magnesium absorption, so they need to be taken on an empty stomach. However, organic magnesium salts (citrate, glycinate, chelate, etc) are more readily absorbed even when taken with food.
Our bodies don’t store magnesium well. It is generally excreted from your system within 24 hours of intake. Therefore, it is important to take magnesium every day.
Magnesium Breakthrough Questions:
What is the B6 in Magnesium Breakthrough made from?
Vitamin B6 improves magnesium absorption and bioavailability. A clinical study compared the effects of magnesium with magnesium combined with B6. They found that subjects who enrolled with severe stress experienced 24% greater reduction in stress scores with magnesium and vitamin B6 compared with magnesium alone. The vitamin B6 in this product is made from carbohydrate fermentation (not potato starch).
Why does this magnesium supplement have rice in it?
When some ingredients are included in very small quantities (milligrams), a carrier substance is necessary. Stabilized rice flour is a naturally-occuring, hypoallergenic, and non-toxic medium that ensures you absorb these ingredients properly.
If you have a rice allergy, we recommend consulting your physician on whether to try this product. We do have a 90-day refund policy.
Why does magnesium help with migraines and headaches?
Magnesium is critical for a healthy nervous system. Magnesium deficiency is a major contributor to neurological problems that may lead to a migraine. A clinical study found that at least 50% of migraine patients have low magnesium, and their symptoms are relieved with magnesium administration. Another study also showed that intravenous magnesium helped with various types of headaches. A clinical trial also showed that magnesium citrate reduced migraine attack frequency by 41.6%, compared to 15.8% in the placebo group. With combined effects of multiple studies, oral magnesium reduces frequency by 20% and attack intensity by 27%. The relief achieved also depends a lot on whether the subjects were deficient in magnesium.
Keep in mind, however, that no magnesium supplement has been FDA-approved to treat or prevent any disease. Magnesium Breakthrough is formulated to be the highest bioavailability (resulting in the most usable to your cells) with the following ingredients:
- Magnesium Chelate and Bisglycinate, which can be absorbed like dipeptides even in compromised gut
- Magnesium Orotate, which is the most bioavailable and beneficial for the heart
- Magnesium Malate, which results in the highest blood and overall tissue levels
- Magnesium Sucrosomial, which has been shown to help with bone health
- Magnesium Taurate, which results in the highest brain and neuronal tissue levels
- Magnesium Citrate, also a highly bioavailable form with neuronal benefits
- Vitamin B6, which promotes magnesium transport into the cells
- Fulvic/Humic acid, which enhances magnesium absorption in the gut
- Manganese, which balances out magnesium and enhance the stress-balancing effects of the formula
The combination of these forms of magnesium, along with other ingredients in the formulation, maximize the absorption while minimizing any side effects. Magnesium Breakthrough also contains the optimal dose of 500 mg elemental magnesium per serving.
Most people only supplement with 1 - 2 forms of magnesium at most, and even then they don’t get the recommended daily intake. A typical magnesium supplement that contains 200 mg total ingredients per capsule contains about 50 - 70 mg of elemental magnesium, requiring at least 5 - 8 capsules to meet even the recommended daily intake dose.
Can you empty the contents into your beverage?
Emptying the contents into a beverage/liquid will not alter magnesium absorption in the body but will definitely influence the taste and not in a good way.
We recommend taking Magnesium Breakthrough® with meals due to it’s laxative effect. If taken on an empty stomach, it may cause diarrhea.
What are the benefits of taking Magnesium Breakthrough?
- 7 types of magnesium makes it the most complete blend available.
- Improves stress levels.
- Improves sleep quality.
- Supports brain function, memory, and cognitive function.
- Helps muscle building and recovery.
- Boosts exercise performance for athletes, the elderly, and people with chronic disease
- Improves mood and relieves depression symptoms. Low levels are linked to an increased risk of depression.
- Improves blood sugar levels even in people with normal blood levels, which means that it will help burn more body fat.
- Reduces PMs symptoms in women: mood, reduce water retention (bloating) and other.
Is this product safe for children?
No. The recommended daily allowance of magnesium for children 9-12 is 240 mg/day which is lower than included in Magnesium Breakthrough®.
How to take magnesium?
Magnesium Breakthrough is best taken on an empty stomach for best absorption. If you get an upset stomach taking it without food, you may want to take it with some food. The recommended daily dosage is 500 mg of elemental magnesium (2 capsules) for general health.
For maximum relaxation, cognitive, and physical performance, some people experience even more benefits when they gradually step their doses up to 5000 mg/day, broken into a few doses. Our bodies are intelligent and can tell how much magnesium you need if you continue to experience improved relaxation and wellbeing. You can take it at any time that works best for you. Taking it in the morning can boost mood by promoting calmness throughout the day. However, many people take it at night to relax before bed and promote more restful deep sleep.
What is the best magnesium supplement?
Not all magnesium supplements are created equal due to the differences in bioavailability.
Bioavailability correlates with health benefits. If the magnesium doesn’t reach your target tissue, you won’t reap the benefits from it.
Magnesium Breakthrough® provides the most bioavailable combination of different forms of magnesium in the market.
Can you take magnesium when pregnant?
For pregnant women, the German Nutrition Society recommends a daily magnesium intake of 310 mg (slightly above the recommended amount for non-pregnant women over the age of 25). This is in part because hormonal changes during pregnancy cause more magnesium is excreted through the urine.
How many capsules in a bottle?
60 Capsules in a bottle.
Frequently Asked Questions:
How to take magnesium for sleep?
To support sleep, take on an empty stomach 1 - 2 hours before bedtime.
How much magnesium should I take for sleep?
It depends on how deficient you are and your individual magnesium needs. If you’re under more physical or emotional stress, you may need more than an average person. Physical stressors include exercise and physical jobs. Vitamin D supplementation (which also helps with sleep) may also increase magnesium needs.
The recommended daily allowance for magnesium is ~400 mg/day for men and ~310 mg for women. However, very few people get this dose from food. If you haven’t taken magnesium for a long time and are deficient, taking the RDA dose can be like filling up an empty pool with a spoon. Therefore, it may be a good idea to start at a higher than the RDA dose to correct the deficiency faster.
Studies have shown benefits of magnesium supplementation from 125 mg to 2500 mg/day. You want to start with 1 - 2 capsules and slowly increase the dosage and observe your body’s response. If you have kidney problems or are on medications that many affect mineral balance (e.g. hypertension medication), it is important to speak to your physician before introducing a magnesium supplement.
Which magnesium is best for anxiety and sleep?
Magnesium chelate, glycinate, citrate, and malate can promote relaxation and sleep. Magnesium Breakthrough contains all of these forms of magnesium.
What can make you deficient in magnesium?
- Mental/emotional stress
- Hard physical exertions
- Caffeine intake
- Being diabetic, or obese
- High doses of vitamin D supplementation
- Calcium and other mineral supplements
- An unhealthy diet with a lot of processed foods
- Alcoholism
- Stomach acid-reducing drugs
- Bisphosphonate drugs for osteoporosis
- Some antibiotics
- Diuretic drugs and blood pressure-reducing drugs
- Kidney disease
- Old age
- Gut issues that affect magnesium absorption, such as Celiac and colitis
If you have a medical condition or are taking medications, consult your physician before introducing any supplements or getting off the medications.
What foods are high in magnesium?
These foods could be high in magnesium if they’re grown in soil that contains it. However, due to modern agricultural practices, most soils are low in magnesium.
- Green leafy vegetables
- Dark chocolate
- Avocado
- Nuts and seeds
Is magnesium better for sleep than melatonin?
Magnesium does different things than melatonin. Melatonin is a nighttime hormone that tells your body it is time to sleep. Whereas, magnesium helps promote a relaxation response as you find down to sleep. There is time and place for both. However, taking high-dose melatonin more than what your body produces (0.35 mg/night) can override your body’s own circadian response. Whereas, taking magnesium provides nutritional insurance to prevent deficiency, which will improve all aspects of health.
Are There Any Side Effects from Magnesium?
Excessive doses of magnesium can cause stomach upset and diarrhea. However, these are much more common with inorganic salts (oxide, chloride, and sulfate) than organic salts (glycinate, chelate, sucrosomial, malate, taurate, etc).
Should You Start Taking Magnesium For Sleep?
Everyone should take magnesium given that the modern lifestyle depletes it and the modern diet doesn’t provide enough. If you have suboptimal sleep, such as taking a long time to fall asleep, waking up tired, or feeling tired in the afternoon, magnesium may help improve your sleep quality.
Product Information
Product Dimensions:
- Cap diameter: 1.5 inches
- Bottom diameter: 2 inches
- Height: 4 inches
- Weight: 3.05 ounces
Caution:
Keep out of reach of children. As with any product, discontinue immediately if adverse effects occur. Please consult a physician before beginning any new supplement, diet, training program, or if you are undergoing treatment of a medical condition.
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Why BiOptimizers Is A Different Kind Of Company
BiOptimizers Was Born From Pain And Passion.
Wade’s passion and mission for helping others optimize their health started when he witnessed his 23-year-old sister pass away from cancer. It was a heart-breaking experience that shaped his destiny. That’s when he realized that health was the most precious asset we have in this life.
Matt’s passion and purpose for helping others started when he helped his best friend lose 191 lbs in 18 months. He watched his friend’s entire life transform as a result. He went from never having a girlfriend to being married in just a couple of years.
Wade Lightheart
President
Matt Gallant
Chief Executive Officer
Wade and Matt were both trainers working with pro athletes and other high performers. They both spent a decade in the gym helping people transform their health. Wade and Matt met in the gym, struck a friendship and then started a business partnership that has been going strong since 2004.
That’s right, we started selling fitness programs, digestive enzymes and organic plant-based protein in 2004. Our obsession to build the best-in-class formulas and solutions just gets stronger. Our policy is, “If we can’t build the best product in that category, forget about it.”
We’re willing to go ALL IN on the formulas. What does this mean? Our average cost per bottle is 200% to 400% higher than most of our competitors. We use the optimal, effective doses of the most researched ingredients. We know that once you experience the results, you’ll be a fan of BiOptimizers for life.
- de Baaij JH, Hoenderop JG, Bindels RJ. Magnesium in man: implications for health and disease. Physiol Rev. 2015;95(1):1-46. doi:10.1152/physrev.00012.2014
- DiNicolantonio JJ, Liu J, O'Keefe JH. Magnesium for the prevention and treatment of cardiovascular disease. Open Heart. 2018;5(2):e000775. Published 2018 Jul 1. doi:10.1136/openhrt-2018-000775
- Boyle NB, Lawton C, Dye L. The Effects of Magnesium Supplementation on Subjective Anxiety and Stress-A Systematic Review. Nutrients. 2017;9(5):429. Published 2017 Apr 26. doi:10.3390/nu9050429
- Pouteau E, Kabir-Ahmadi M, Noah L, et al. Superiority of magnesium and vitamin B6 over magnesium alone on severe stress in healthy adults with low magnesemia: A randomized, single-blind clinical trial. PLoS One. 2018;13(12):e0208454. Published 2018 Dec 18. doi:10.1371/journal.pone.0208454
- Eby GA, Eby KL. Rapid recovery from major depression using magnesium treatment. Med Hypotheses. 2006;67(2):362-370. doi:10.1016/j.mehy.2006.01.047
- Tarleton EK, Littenberg B, MacLean CD, Kennedy AG, Daley C. Role of magnesium supplementation in the treatment of depression: A randomized clinical trial. PLoS One. 2017;12(6):e0180067. Published 2017 Jun 27. doi:10.1371/journal.pone.0180067
- Botturi A, Ciappolino V, Delvecchio G, Boscutti A, Viscardi B, Brambilla P. The Role and the Effect of Magnesium in Mental Disorders: A Systematic Review. Nutrients. 2020;12(6):1661. Published 2020 Jun 3. doi:10.3390/nu12061661
- Barragán-Rodríguez L, Rodríguez-Morán M, Guerrero-Romero F. Efficacy and safety of oral magnesium supplementation in the treatment of depression in the elderly with type 2 diabetes: a randomized, equivalent trial. Magnes Res. 2008;21(4):218-223.
- Guerrero-Romero F, Tamez-Perez HE, González-González G, et al. Oral magnesium supplementation improves sensitivity in non-diabetic subjects with resistance. A double-blind placebo-controlled randomized trial. Diabetes Metab. 2004;30(3):253-258. doi:10.1016/s1262-3636(07)70116-7
- Takaya J, Higashino H, Kobayashi Y. Intracellular magnesium and resistance. Magnes Res. 2004;17(2):126-136.
- Schnack C, Bauer I, Pregant P, Hopmeier P, Schernthaner G. Hypomagnesaemia in type 2 diabetes mellitus is not corrected by improvement of long-term metabolic control. Diabetologia. 1992;35(1):77-79. doi:10.1007/BF00400855
- Rodríguez-Morán M, Guerrero-Romero F. Oral magnesium supplementation improves sensitivity and metabolic control in type 2 diabetic subjects: a randomized double-blind controlled trial. Diabetes Care. 2003;26(4):1147-1152. doi:10.2337/diacare.26.4.1147
- Askari M, Mozaffari H, Jafari A, Ghanbari M, Darooghegi Mofrad M. The effects of magnesium supplementation on obesity measures in adults: a systematic review and dose-response meta-analysis of randomized controlled trials [published online ahead of print, 2020 Jul 11]. Crit Rev Food Sci Nutr. 2020;1-17. doi:10.1080/10408398.2020.1790498
- Asemi Z, Karamali M, Jamilian M, et al. Magnesium supplementation affects metabolic status and pregnancy outcomes in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Am J Clin Nutr. 2015;102(1):222-229. doi:10.3945/ajcn.114.098616
- Zhang Y, Xun P, Wang R, Mao L, He K. Can Magnesium Enhance Exercise Performance?. Nutrients. 2017;9(9):946. Published 2017 Aug 28. doi:10.3390/nu9090946
- Córdova A, Mielgo-Ayuso J, Roche E, Caballero-García A, Fernandez-Lázaro D. Impact of Magnesium Supplementation in Muscle Damage of Professional Cyclists Competing in a Stage Race. Nutrients. 2019;11(8):1927. Published 2019 Aug 16. doi:10.3390/nu11081927
- Abbasi B, Kimiagar M, Sadeghniiat K, Shirazi MM, Hedayati M, Rashidkhani B. The effect of magnesium supplementation on primary insomnia in elderly: A double-blind placebo-controlled clinical trial. J Res Med Sci. 2012;17(12):1161-1169.
- Castiglioni S, Cazzaniga A, Albisetti W, Maier JA. Magnesium and osteoporosis: current state of knowledge and future research directions. Nutrients. 2013;5(8):3022-3033. Published 2013 Jul 31. doi:10.3390/nu5083022
- Orchard TS, Larson JC, Alghothani N, et al. Magnesium intake, bone mineral density, and fractures: results from the Women's Health Initiative Observational Study. Am J Clin Nutr. 2014;99(4):926-933. doi:10.3945/ajcn.113.067488
- Zhang X, Li Y, Del Gobbo LC, et al. Effects of Magnesium Supplementation on Blood Pressure: A Meta-Analysis of Randomized Double-Blind Placebo-Controlled Trials. Hypertension. 2016;68(2):324-333. doi:10.1161/HYPERTENSIONAHA.116.07664
- Tam M, Gómez S, González-Gross M, Marcos A. Possible roles of magnesium on the immune system. Eur J Clin Nutr. 2003;57(10):1193-1197. doi:10.1038/sj.ejcn.1601689
- Moslehi N, Vafa M, Rahimi-Foroushani A, Golestan B. Effects of oral magnesium supplementation on inflammatory markers in middle-aged overweight women. J Res Med Sci. 2012;17(7):607-614.
- Kim DJ, Xun P, Liu K, et al. Magnesium intake in relation to systemic inflammation, resistance, and the incidence of diabetes. Diabetes Care. 2010;33(12):2604-2610. doi:10.2337/dc10-0994
- Nielsen FH. Magnesium deficiency and increased inflammation: current perspectives. J Inflamm Res. 2018;11:25-34. Published 2018 Jan 18. doi:10.2147/JIR.S136742
- Uwitonze AM, Razzaque MS. Role of Magnesium in Vitamin D Activation and Function. J Am Osteopath Assoc. 2018;118(3):181-189. doi:10.7556/jaoa.2018.037
- Sartori SB, Whittle N, Hetzenauer A, Singewald N. Magnesium deficiency induces anxiety and HPA axis dysregulation: modulation by therapeutic drug treatment. Neuropharmacology. 2012;62(1):304-312. doi:10.1016/j.neuropharm.2011.07.027
- Jacka FN, Overland S, Stewart R, Tell GS, Bjelland I, Mykletun A. Association between magnesium intake and depression and anxiety in community-dwelling adults: the Hordaland Health Study. Aust N Z J Psychiatry. 2009;43(1):45-52. doi:10.1080/00048670802534408
- Grases G, Pérez-Castelló JA, Sanchis P, et al. Anxiety and stress among science students. Study of calcium and magnesium alterations. Magnes Res. 2006;19(2):102-106.
- Takase B, Akima T, Uehata A, Ohsuzu F, Kurita A. Effect of chronic stress and sleep deprivation on both flow-mediated dilation in the brachial artery and the intracellular magnesium level in humans. Clin Cardiol. 2004;27(4):223-227. doi:10.1002/clc.4960270411
- Boyle NB, Lawton C, Dye L. The Effects of Magnesium Supplementation on Subjective Anxiety and Stress-A Systematic Review. Nutrients. 2017;9(5):429. Published 2017 Apr 26. doi:10.3390/nu9050429
- Caillard, V. (1992). Sanofi Internal report MAB6-32. Paris, France. Unpublished work.
- Boyle NB, Lawton C, Dye L. The Effects of Magnesium Supplementation on Subjective Anxiety and Stress-A Systematic Review. Nutrients. 2017;9(5):429. Published 2017 Apr 26. doi:10.3390/nu9050429
- Pouteau E, Kabir-Ahmadi M, Noah L, et al. Superiority of magnesium and vitamin B6 over magnesium alone on severe stress in healthy adults with low magnesemia: A randomized, single-blind clinical trial. PLoS One. 2018;13(12):e0208454. Published 2018 Dec 18. doi:10.1371/journal.pone.0208454
- Bøhmer T, Røseth A, Holm H, Weberg-Teigen S, Wahl L. Bioavailability of oral magnesium supplementation in female students evaluated from elimination of magnesium in 24-hour urine. Magnes Trace Elem. 1990;9(5):272-278.
- Firoz M, Graber M. Bioavailability of US commercial magnesium preparations. Magnes Res. 2001;14(4):257-262.
- Uysal N, Kizildag S, Yuce Z, et al. Timeline (Bioavailability) of Magnesium Compounds in Hours: Which Magnesium Compound Works Best? Biol Trace Elem Res. 2019;187(1):128-136. doi:10.1007/s12011-018-1351-9
- Reddy P, Edwards LR. Magnesium Supplementation in Vitamin D Deficiency. Am J Ther. 2019;26(1):e124-e132. doi:10.1097/MJT.0000000000000538
- Magnesium Fact Sheet for Health Professionals. Ods.od.nih.gov. Accessed February 23, 2021.
